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KMID : 0984720030350050332
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Infection and Chemotherapy
2003 Volume.35 No. 5 p.332 ~ p.336
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Two Cases of Aspergillus Endocarditis in Patients with Acute Lymphoblastic Leukemia
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Shin Sung-Chul
Peck Kyong-Ran
Jung Jae-Hong
Song Bong-Geun
Kim Dong-Hee
Jeon Kyeong-Man
Chae Je-Wook
Son Jun-Seong
Jung Sook-In
Oh Won-Sup
Song Jae-Hoon
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Abstract
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Although Aspergillus endocarditis has rarely been reported, it can cause fatal complications in hematologic malignancy patients and allogeneic stem cell transplant recipients. We experienced two cases of aspergillus endocarditis developed in acute lymphoblastic leukemia patients. Case; A 19yearold patent developed Aspergillus endocarditis after allogenic hemopoietic stem cell transplantation. He was treated with surgical intervention and liposomal amphotericin B. He died of recurred Aspergillus endocarditis and cerebral hemorrhage probably related with aspergillosis of central nervous system. Case 2; A 23yearold patient developed invasive Aspergillus endocarditis after induction chemotherapy. Aspergillus endocarditis was successfully treated by surgical intervention and amphotericin B. He died of refractory neutropenic fever and sepsis after the third relapse of leukemia and repetitive chemotherapy. He probably had invasive pulmonary aspergillosis without evidence of endocarditis recurrence. Because the mortality of Aspergillus endocarditis is very high, early diagnosis and surgical intervention are very important for better outcome.
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KEYWORD
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Aspergillosis, Leukemia, Endocarditis, Osteomyelitis
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